Lymph organs

The immune system is made up of organs that control the production and maturation of certain defense cells, the lymphocytes. Bone marrow and the thymus, a gland situated above the heart and behind the breast bone, are so-called primary lymphoid organs.

The bone marrow produces defense cells. Some of these defense cells, the so-called T lymphocytes (T stands for thymus), are differentiated in the thymus. That means that this is where they develop into cells that are capable of recognizing non-self proteins, so-called antigens.

The secondary lymphatic organs are the place where the defense cells do their actual work. These organs include the lymph nodes, the spleen, the tonsils and other specialized tissues in the mucous membranes of the bowel, for example. In these places, the defense cells have constant contact with non-self substances and pathogens.

Bone marrow

Bone marrow is a sponge-like tissue situated inside of the bones. Most defense cells are produced and then also multiply here. They then migrate from the bone marrow into the bloodstream and reach other organs and tissues, where the defense cells mature and specialize. At birth, many bones contain red bone marrow, which actively builds defense cells. During the course of life, more and more red bone marrow turns into fat tissue. Adults only have red bone marrow in a few bones, for example in the ribs, in the breast bone and in the pelvic bone.

Thymus

The thymus, also called the thymus gland, is fully developed in children. From adolescence onwards, it slowly turns into fatty tissue. The gland-like organ is situated behind the breast bone above the heart. Certain defense cells are differentiated in the thymus: particularly the so-called T lymphocytes (or T-cells for short) which are responsible for coordinating our innate and adaptive parts of our immune system.

The T in T lymphocytes stands for Thymus, and notes the place where the T-Cells mature. T-Cells move through the body and constantly watch the surfaces of all cells for changes. To be able to do this job, they learn in the thymus which structures on cell surfaces are self and which are non-self.

When coming into contact with a “non-self body,” T-Cells turn into so-called T Effector Cells, which trigger and regulate different defense reactions. This type of cells includes T Killer Cells, which can destroy cells infected with a pathogen. T Helper Cells are another kind of effector cells, which support other immune cells in doing their work.

In childhood, the thymus tissue also produces two hormones – thymosin and thymopoietin – which regulate the maturation of defense cells in the lymph nodes.

Lymph nodes

The lymphatic system of lymph nodes and vessels is works to continually exchanging substances between the blood and the tissue in the body. Fluid constantly leaves the blood, and defense cells and proteins migrate into the surrounding tissue. Most of the fluid is later taken back into the blood vessels.

The rest of the excess cell fluids are removed by a drainage system of our lymph vessels, which forms a fine net of thin-walled vessels in the body. The lymph nodes filter and clean the lymph fluid (lymph) on its way to the larger lymph vessels. The lymph finally travels to a vein called the Superior Vena Cava, where it enters the bloodstream.

Lymph nodes work like biological filter stations. They contain different defense cells, which trap pathogens and activate the production of specific antibodies in the blood. If lymph nodes become swollen, painful or hard, it can be a sign of an active defense response, for example in an infection or, in rare cases, in malignant changes of the body’s own cells.

Spleen

The spleen is located in the left upper abdomen, beneath the diaphragm. It has a variety of tasks in the defense system. During fetal development, the spleen mainly produces blood and defense cells. After birth this organ is mainly responsible for removing old blood cells and for immune defense functions. As part of the immune defense, the functions of the spleen include the following:

• It stores different defense cells that are released into the blood to get to the organs, if needed: macrophages, also called scavenger cells, can attack non-self substances and pathogens directly. T Lymphocytes inspect cell surfaces, help in controlling defense and can also directly destroy cells that have been recognized as non-self or as pathogens. B Lymphocytes produce antibodies, if needed.
• It is responsible for removing red blood cells (erythrocytes).
• Blood platelets (thrombocytes), which are responsible for blood clotting together, are stored and removed in the spleen.

So there is always a lot of blood flowing through the spleen tissue. At the same time this tissue is very soft. In heavy injuries, in an accident, for example, the spleen can therefore rupture easily. The spleen then needs to be operated on, because otherwise there is a danger of bleeding to death. If the bleeding cannot be stopped, and the spleen has to be removed, other defense organs take on most of its tasks.

Tonsils

Tonsils also belong to the immune defense system. Due to their special position at the throat and palate, their defense cells quickly come into contact with airborn pathogens, and can activate the immune system immediately. Their tissue contains mainly lymphocytes. In addition to the palatine tonsils on the right and left side, which are commonly just called tonsils, there are also the adenoids above the roof of the throat, the lingual tonsil at the base of the tongue, and more lymphatic tissue on the sides of the throat. This lymphatic tissue can take on the function of the adenoids, if these have been removed.

Lymphatic tissue in the bowel and in other mucous membranes in the body

The bowel plays a central role in defending the body against pathogens: more than half of all cells that produce antibodies are found in the bowel wall, especially in the last part of the small bowel and in the appendix. These cells recognize pathogens and other non-self substances, then mark and destroy them. They also store information on these non-self substances to be able to react faster the next time. The large bowel also always contains bacteria that belong to the body, the so-called gut flora. These bacteria in the large bowel make it difficult for other pathogens to settle and to enter the body. The immune system of the bowel tolerates the bacteria of the gut flora.

Other parts of the body where pathogens may enter also contain lymphatic tissue in the mucous membranes. All this tissue together is also called Mucosa-Associated Lymphoid Tissue (MALT). Pathogens might enter the body through the airways or the urinary tract, for example. Lymphatic tissue can be found in the bronchi and in the mucous membranes of the nose, the urinary bladder and the vagina with the defense cells being directly beneath the mucous membrane where they prevent bacteria and viruses from attaching.

Sources

• InformedHealth.org [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. What are the organs of the immune system? 2010 Nov 30 [Updated 2016 Jan 20]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK279395/
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• Pschyrembel W. Klinisches Wörterbuch. Berlin: De Gruyter; 2014.
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